Over 14 million people in the US are suffering from the life altering symptoms of Long Covid. Our research team is recognized for the discovery of the root cause of Long Covid symptoms.
Thousands of patients have experienced significant symptom relief after being diagnosed and treated by our highly trained staff of Physicians and Nurse Practitioners.
We look forward to the opportunity of helping you return to your normal life.
For more information click on the buttons below.
Where over 7,000 patients have successfully defeated their Long Covid symptoms
What is Long Covid?
The root cause of Long Covid symptoms is vascular inflammation. Vascular inflammation occurs when proteins from the Covid-19 virus are captured by specific white blood cells from your body’s immune system.
These white blood cells travel all over your body including crossing the blood brain barrier inflaming the endothelium cells that line your blood vessels, causing wide spread chronic symptoms.
For more information click on the video below that helps explain The Origins of Long Covid Symptoms.
Do You Have Long Covid?
The most common Long Covid symptoms are fatigue, brain fog and breathing difficulties.
Physicians cannot confirm Long Covid vs. other chronic conditions like Chronic Lyme or Chronic Fatigue Syndrome without a definitive diagnostic test.
Their treatment decisions are often based on patient directed questionnaires that rank the severity of each symptom on a scale of 1-10.
Unfortunately, these treatments do not target vascular inflammation which is the primary root cause of Long Covid.
There is now a diagnostic test that quantitatively identifies the biomarker signature for Long Covid via a simple blood test.
This test is administered under the trade name IncellKINE™ by Radiance Diagnostic laboratory.
If you are interested in ordering the test, click on the ORDER TEST button on the right corner and it will link you to the process for ordering the test from Radiance Diagnostic Laboratory.
Long Covid Symptoms
What Are Your Treatment Options?
The key to minimizing or eliminating Long Covid symptoms is to target the biomarkers that are responsible for causing vascular inflammation.
Vascular inflammation occurs when specific white blood cells with Covid proteins migrate throughout the body releasing pro-inflammatory cytokines and chemokines to signal more inflammation.
One of these chemokines is CCR5 and is secreted by both the immune and endothelial cells. Another is called fractalkine which acts like Velcro causing the specific white blood cells to stick to the endothelial cells that line blood vessels.
Successful treatment of Long Covid requires the prevention of these specific white blood cells from migrating to other parts of the body by blocking the effects of CCR5 and fractalkine cytokines.
Fortunately, there are two prescription therapeutics that when used in combination, frequently accomplish this objective.
Maraviroc (CCR5 antagonist) and Pravastatin (fractalkine inhibitor) are both commercially available.
These therapeutics were investigated and published in a paper entitled “Case series: Maraviroc and pravastatin as a therapeutic option to treat long COVID/Post-acute sequelae of COVID (PASC). This study link is below for your reference: (CLICK HERE FOR STUDY PAPER)
In a recent Harvard study 3,925 patients were surveyed regarding the effectiveness of 150 Long Covid treatments. The therapeutic that received the highest ranking was Maraviroc. This study link is below for your reference: (CLICK HERE FOR STUDY PAPER)
Next Steps
If you or your loved one is interested in pursuing diagnosis and treatment for your Long Covid Symptoms, the following is a brief overview of the process:
Step One: Determine if you have Long Covid by ordering the IncellKINE™ diagnostic test from Radiance Diagnostic Laboratory. Click on the ORDER TEST button on right corner for detailed ordering instructions.
Step Two: Receive test result directly from Radiance Laboratories.
Step Three: Sharing test results
a.) Share the test results with your personal physician who will interpret the test result and prescribe the appropriate therapy.
b.) Alternatively, you can schedule an appointment with one of the Long Covid medical specialists who will interpret your test result and answer your questions. In either case, your personal physician will prescribe the appropriate therapy for you.
Ordering Diagnostic Test
The first step towards eliminating your Long Covid symptoms is to determine if you have vascular inflammation, the primary cause of Long Covid illness. The good news is there are targeted combination therapeutics that will resolve vascular inflammation, but you will first need to be tested to confirm your Long Covid diagnosis.
The name of the diagnostic test is IncellKINE™. It is designed to detect a unique biomarker signature for patients being tested for Long Covid.
The test was clinically validated to distinguish between three COVID-19 patient groups (Mild-Moderate, Severe, Long COVID) compared to healthy patients. The test was found to be statistically significant, and the results were published in Frontiers in Immunology (CLICK HERE FOR STUDY PAPER)
As a patient in the US/Canada, the following steps will help you secure your diagnostic test
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Click HERE to place order with our lab partner
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Once you place an order with Radiance Diagnostics they will send a blood collection kit to your home. You will need to have a blood phlebotomist collect the blood sample and return to Radiance Diagnostics Laboratory in the Fed-Ex shipping container supplied in collection kit.
IMPORTANT: You can contact a local phlebotomist (blood draw service) to draw your blood sample or ask your local physician if they can complete this step.
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Once sample is received back at Radiance Lab, they run the sample within 10 days of receipt and send your personalized diagnostic results to you via email
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Once your test results are completed, you will receive an email with your results along with a link that you can share with your medical provider. The link provides a clinical video explaining the diagnostic test and how to interpret the results.
Your provider will then review and determine your treatment options. They will prescribe you medication as needed.
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If you would prefer to schedule a TeleMed consult with one of our Long Covid trained medical providers, you can do so once you have received your test results.
Following your consultation, a summary report will be created for you to share with your medical provider. Your personal physician is responsible for prescribing treatment therapeutics.
Payments
Lab test cost: Radiance Diagnostic Laboratory will require payment for the test prior to sending you the blood collection test. Radiance charges $460 for the test.
The Lab will provide you with a Super bill with your payment, which is an itemized document that lists the diagnostic test you received. You can submit Super bill to your insurance company to request reimbursement. It will include codes for the test, the cost, and other relevant details needed for the insurance claim process.
Optional telemedicine consultation: You can choose to independently share your test results with your primary care provider. Important: Your personal physician is responsible for prescribing treatment therapeutics.
Telemedicine consultation cost: The Long Covid Trained Physicians charge $250 for the medical consultation which includes interpretation of test results, answering your questions and writing a summary report that you can share with your personal physician.
Disclaimer
While we provide a superbill to assist with your reimbursement claim, insurance coverage is not guaranteed. Reimbursement depends on your insurance provider’s policies, criteria, and the specifics of your plan. We recommend contacting your insurance company directly to confirm eligibility before submitting the super bill.
The information provided on this website is for informational purposes only and is sourced from publicly available clinical studies and medical literature. The Advanced Long Covid Treatment Center does not guarantee that any treatment or therapy will yield the same results for all patients. Individual outcomes may vary, and past patient responses do not predict future results.
HealthBio has been granted approval by the FDA to conduct a randomized, double-blind, placebo-controlled trial for the combination therapy Maraviroc and Pravastatin for treating Long Covid patients. However, inclusion in any study is subject to specific eligibility criteria and medical evaluation.
Disclosures
This website does not provide medical advice, nor does it assume any responsibility for its contents. Patients should consult with their healthcare provider before making any medical decisions.
The creator of this site, Advance Long Covid Treatment Center, has no financial relationship with either IncellDx, HealthBio or Radiance Diagnostics. This site does not collect any financial payments as they are collected by the Laboratory running the diagnostic test and from those trained physicians completing the optional TeleMed consultation.
Patient Stories and Outcomes
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Cliff Richey’s Five-Set Match With Long COVID.
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Update from Mom and Dad
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Jeff's Update: "I cannot tell you how much better I feel after 8 weeks. I can think again and my energy levels have returned to baseline."
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Katie's Update: "I am so blessed to have found you. My life was a mess and now I can actually think about going back to work."
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Ethan's Update: "I cannot believe how much better I am. For a year I tried everything and this protocol made the difference."
Resources
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Persistence of SARS-CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC)
Hyperlink: Link to Study
Date: 09 January 2022
Authors:
Patterson, B.K; Francisco, E.B; Yogendra, R; Long, E; Pise, A; Rodrigues, H; Hall, E; Herrera, M; Parikh, P; Guevara-Coto, J; Triche, T.J.
This study investigates how lingering viral components may drive the persistent symptoms of Long COVID (PASC). Researchers evaluated immune markers in 144 individuals across mild, moderate, and severe COVID-19, as well as PASC cases. A key finding is that the S1 protein—a component of SARS-CoV-2—can remain in CD16+ monocytes for up to 15 months post-infection, even when the virus itself is undetectable.
Two notable findings underscore potential mechanisms of Long COVID:
Elevated Non-Classical Monocytes: PASC patients exhibited significantly higher levels of these CD16+ cells than healthy controls.
Residual Viral Fragments: These monocytes contained the S1 protein but lacked full viral RNA, suggesting inflammation arises from fragments rather than active replication.
Advanced analytical methods confirmed that this residual protein can trigger immunological and inflammatory pathways, possibly explaining chronic symptoms such as fatigue, cognitive issues, and ongoing inflammation.
Hyperlink: Link to Study
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Hyperlink: Link to Study
Authors: Patterson, B.K; Yogendra, R; Guevara-Coto, J; Mora-Rodriguez, R.A; Osgood, E; Bream, J; Parikh, P; Kreimer, M; Jeffers, D; Rutland, C; Kaplan, G
Date: 14 May 2024
This case series explores the potential of maraviroc and pravastatin as treatments for Long COVID, a condition characterized by persistent symptoms such as fatigue, brain fog, and breathing difficulties. The study included 18 participants with confirmed SARS-CoV-2 infection and symptoms lasting over three months, assessing the effects of these drugs on inflammation and immune regulation.
1. Targeted therapeutic approach: Maraviroc, a CCR5 receptor blocker, and pravastatin, an anti-inflammatory statin, were used to modulate immune and vascular inflammation associated with Long COVID.
2. Clinical improvements observed: Over 6 to 12 weeks, patients showed significant symptom relief across validated scales, including the Fatigue Severity Scale and COMPASS-31 autonomic dysfunction questionnaire, with reductions in inflammatory markers like VEGF and sCD40L.
These promising findings highlight a potential therapeutic strategy for PASC, providing a strong rationale for larger, randomized controlled trials to confirm efficacy and offer relief to affected individuals worldwide.
Hyperlink: Link to Study
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Hyperlink: Link to Study
Authors: Patterson, B.K; Guevara-Coto, J; Yogendra, R; Francisco, E.B; Long, E; Pise, A; Rodrigues, H; Parikh, P; Mora, J; Mora-Rodríguez, R.A.
Date: 27 June 2021
This research aimed to identify immune markers that predict COVID-19 severity and the risk of Long COVID (PASC) using advanced machine learning techniques. Blood samples from 224 individuals, including healthy controls, mild-to-moderate COVID-19 cases, severe cases, and Long COVID patients, were analyzed to uncover distinct immune profiles.
1. Key immune markers identified: Severe and PASC patients showed elevated inflammatory markers, including CCL5 (RANTES), IL-6, and VEGF, while PASC patients exhibited reduced regulatory T cells and CD4/CD8 T cells expressing PD-1, suggesting persistent immune dysregulation.
2. Machine learning for risk prediction: Models such as random forest classifiers effectively differentiated patient groups with high accuracy, predicting disease severity and identifying individuals at risk of developing PASC.
3. Quantitative immune scoring for treatment guidance: The study introduced the Long Hauler Index (LHI), defined as LHI = (IL-2 + IFN-γ) / CCL4, highlighting cytokines' role in immune dysregulation and offering a potential biomarker for monitoring Long COVID.
By combining machine learning and immune profiling, this research advances precision medicine for COVID-19, providing tools to predict outcomes and guide treatment strategies.
Hyperlink: Link to Study
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Hyperlink: Link to Study
Authors: Patterson, B.K; Guevara-Coto, J; Mora, J; Francisco, E.B; Yogendra, R; Mora-Rodríguez, R.A; Beaty, C; Lemaster, G; Kaplan DO, G; Katz, A; Bellanti, J.A.
Date: 26 August 2024
This study addresses the diagnostic challenges of Long COVID (LC) and Chronic Lyme Disease (CLD), two conditions with overlapping symptoms like fatigue, brain fog, and post-exertional malaise. Researchers analyzed cytokine profiles from 347 individuals, including LC patients, CLD patients, and healthy controls, using machine learning to create a diagnostic tool that distinguishes between LC and CLD with high accuracy.
Machine learning for precision diagnosis: The study employed tree-based machine learning models, including gradient-boosting machines (GBMs), which achieved 97% sensitivity and 90% specificity in differentiating LC from CLD in blinded tests.
Cytokine-based Lyme Index: Researchers developed a Lyme Index with two features derived from cytokine profiles to further confirm CLD diagnoses:
Feature 1: (TNF-α + IL-4) / (IFN-γ + IL-2)
These features were selected for their immunological relevance to CLD and LC, enhancing diagnostic precision by distinguishing between the two conditions and reducing errors from overlapping symptoms. The study underscores the distinct immune pathways involved, highlighting the importance of precision diagnostics for tailored treatment. By leveraging immune biomarkers and machine learning, the Lyme Index represents a significant advancement in diagnosing chronic inflammatory diseases.
Hyperlink: Link to Study
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Press Release - February 13, 2025
Today marks an important day as we unveil our latest initiatives aimed at raising awareness and combating the challenges associated with Long Covid. We are committed to providing support and resources for those affected, ensuring they have access to the information and assistance necessary for their journey toward recovery. Our team continues to work diligently to foster collaboration and share valuable insights within the community.